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全球健康药物研发中心(GHDDI)入驻仪式在京举行,机构发展开启全新篇章
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论文发表
新闻
论文发表
2025/04/15
mLife
Identification of a phenyl ester covalent inhibitor of caseinolytic protease and analysis of the ClpP1P2 inhibition in mycobacteria
Genhui Xiao, Yumeng Cui, Liangliang Zhou, Chuya Niu, Bing Wang, Jinglan Wang, Shaoyang Zhou, Miaomiao Pan, Chi Kin Chan, Yan Xia, Lan Xu, Yu Lu, Shawn Chen.
mLife DOI: https://doi.org/10.1002/mlf2.12169
2024/12/25
International Journal of Drug Delivery Technology
Enhanced Oral Absorption and Bioavailability of Ivermectin Through Amorphous Solid Dispersion Techniques
Yu Chang, Jing Li, Zhiyang Zack Zou
International Journal of Drug Delivery Technology DOI: https://doi.org/10.25258/ijddt.14.4.X
2024/12/04
Molecules
Insights into the Metabolism, Disposition, and Quantitative Profile of mGlu5 NAM AE90015 with Metabolite Identification and a Novel Integration Method
Zhiyang Zack Zou, Ming-Jie Han, Yu Chang and Guiying Li
Molecules DOI: https://doi.org/10.3390/molecules29235724
2024/12/03
Parasites & Vectors
Repurposing of a library for high-content screening of inhibitors against Echinococcus granulosus
Weinan Zheng, Gaofei Lv, Jun Li, Yao Zhang, Wenjing Qi, Mingzhi Yan, Jinzhi Wu, Chikin Chan, Xiaoben Pan & Wenbao Zhang
Parasites & Vectors DOI: https://doi.org/10.1186/s13071-024-06456-6
2024/11/29
Science
Systematic in vitro evolution in Plasmodium falciparum reveals key determinants of drug resistance
Madeline R. Luth, Karla P. Godinez-Macias, Daisy Chen, John Okombo, Vandana Thathy, Xiu Cheng, el al.
Science DOI: https://doi.org/10.1126/science.adk9893
2024/10/29
Nature Communications
TamGen: drug design with target-aware molecule generation through a chemical language model
Kehan Wu, Yingce Xia, Pan Deng, Renhe Liu, Yuan Zhang, Han Guo, Yumeng Cui, Qizhi Pei, Lijun Wu, Shufang Xie, Si Chen, Xi Lu, Song Hu, Jinzhi Wu, Chi-Kin Chan, Shawn Chen, Liangliang Zhou, Nenghai Yu, Enhong Chen, Haiguang Liu, Jinjiang Guo, Tao Qin & Tie
Nature Communications DOI: https://doi.org/10.1038/s41467-024-53632-4
2024/10/29
RPS Pharmacy and Pharmacology Reports
Enhancing the in vivo bioavailability and absorption of Niclosamide with amorphous solid dispersion via solvent method
Jing Li, Yu Chang, Zhiyang Zack Zou
RPS Pharmacy and Pharmacology Reports DOI: https://doi.org/10.1093/rpsppr/rqae025
2024/07/17
Scientific Reports
In Silico drug repurposing pipeline using deep learning and structure based approaches in epilepsy
Xiaoying Lv, Jia Wang, Ying Yuan, Lurong Pan, Qi Liu, Jinjiang Guo
Scientific Reports DOI: https://doi.org/10.1038/s41598-024-67594-6
2024/03/18
European Journal of Pharmaceutical Sciences
Enabling a novel solvent method on Albendazole solid dispersion to improve the in vivo bioavailability
Ming-Jie Han, Zhiyang Zack Zou
European Journal of Pharmaceutical Sciences DOI: https://doi.org/10.1016/j.ejps.2024.106751
2023/11/27
Human Gene Therapy
Drug Repositioning for Amyloid Transthyretin Amyloidosis by Interactome Network Corrected by Graph Neural Networks and Transcriptome Analysis
Shan He, XiaoYing Lv, XinYue He, JinJiang Guo, RuoKai Pan, YuTong Jin, Zhuang Tian, LuRong Pan, ShuYang Zhang
Human Gene Therapy DOI: https://doi.org/10.1089/hum.2021.222
2023/10/11
Journal of Medical Virology
Alleviated symptoms of SARS-CoV-2 Omicron variant infection in chronic hepatitis B patients with immune control
Jing Liu, Huiqing Zhang, Jianing Kong, Shiyi Liu, Liping Chen, Yanming Jiang, Jie Wang, Binbin Zhang, Xiaoping Ye, Ling Gong, Xiang Zhou, Gongying Chen, Jie Li, Xiaoben Pan, el al.
Journal of Medical Virology DOI: https://doi.org/10.1002/jmv.29173
2023/06/10
British Journal of Pharmacology
Advances in malaria pharmacology and the online guide to MALARIA PHARMACOLOGY: IUPHAR review 38
Armstrong JF, Campo B, Alexander SPH, Arendse LB, Cheng X, …, Sakata-Kato T, el al.
British Journal of Pharmacology DOI: https://doi.org/10.1111/bph.16144
2023/06/08
Molecules
Assessing Boron-Pleuromutilin AN11251 for the Development of Antibacterial Agents
Ming-Jie Han, Miaomiao Pan, Genhui Xiao, Ying Yuan, Shawn Chen, and Zhiyang Zou
Molecules DOI: https://doi.org/10.3390/molecules28124628
2023/03/08
Science Translational Medicine
Cytoplasmic isoleucyl tRNA synthetase as an attractive multistage antimalarial drug target
Eva S. Istvan, Franciso Guerra, Matthew Abraham, Kuo-sen Huang, Frances Rocamora, Haoshuang Zhao, Lan Xu, el al.
Science Translational Medicine DOI: https://doi.org/10.1126/scitranslmed.adc9249
2022/09/01
ACS Infectious Diseases
Human Kinase IGF1R/IR Inhibitor Linsitinib Controls the In Vitro and Intracellular Growth of Mycobacterium tuberculosis
Heng Wang, Jing Bi, Yuan Zhang, Miaomiao Pan, Qinglong Guo, Genhui Xiao, Yumeng Cui, Song Hu, Chi Kin Chan, Ying Yuan, Takushi Kaneko, Guoliang Zhang, and Shawn Chen
ACS Infectious Diseases DOI: https://doi.org/10.1021/acsinfecdis.2c00278
2022/08/26
Methods in Enzymology
Developed a streamlined process for discovery and characterization of inhibitors against phenylalanyl-tRNA synthetase of Mycobacterium tuberculosis
Heng Wang, Shawn Chen
Methods in Enzymology DOI: https://doi.org/10.1016/bs.mie.2022.07.032
2022/02/21
arXiv
Ligandformer: A Graph Neural Network for Predicting Compound Property with Robust Interpretation
Jinjiang Guo, Qi Liu, Han Guo, Xi Lu
arXiv DOI: https://doi.org/10.48550/arXiv.2202.10873
2021/12/05
ACS Chem Biology
Investigate Natural Product Indolmycin and the Synthetically Improved Analogue Toward Antimycobacterial Agents
Yuhong Yang, Yuanyuan Xu, Yuan Yue, Heng Wang, Yumeng Cui, Miaomiao Pan, Xi Zhang, Lin Zhang, Haitao Li, Min Xu, Yefeng Tang, and Shawn Chen
ACS Chem Biology DOI: https://doi.org/10.1021/acschembio.1c00394
2021/02/21
arXiv
Sequence-based deep learning antibody design for in silico antibody affinity maturation
Yue Kang, Dawei Leng, Jinjiang Guo, Lurong Pan
arXiv DOI: https://doi.org/10.48550/arXiv.2103.03724
2021/02/09
arXiv
Real-time tracking of COVID-19 and coronavirus research updates through text mining
Yutong Jin, Jie Li, Xinyu Wang, Peiyao Li, Jinjiang Guo, Junfeng Wu, Dawei Leng, Lurong Pan
arXiv DOI: https://doi.org/10.48550/arXiv.2102.07640
2021/02/08
arXiv
Enhance Information Propagation for Graph Neural Network by Heterogeneous Aggregations
Dawei Leng, Jinjiang Guo, Lurong Pan, Jie Li, Xinyu Wang
arXiv DOI: https://doi.org/10.48550/arXiv.2102.04064
2021/02/08
arXiv
ParaVS: A Simple, Fast, Efficient and Flexible Graph Neural Network Framework for Structure-Based Virtual Screening
Junfeng Wu, Dawei Leng, Lurong Pan
arXiv DOI: https://doi.org/10.48550/arXiv.2102.06086
2021/01/28
arXiv
Heterogeneous Graph based Deep Learning for Biomedical Network Link Prediction
Jinjiang Guo, Jie Li, Dawei Leng, Lurong Pan
arXiv DOI: https://doi.org/10.48550/arXiv.2102.01649
2021/01/08
J Biol Chem
Rediscovery of PF-3845 as a new chemical scaffold inhibiting phenylalanyl-tRNA synthetase in Mycobacterium tuberculosis
Heng Wang, Min Xu, Curtis A Engelhart, Xi Zhang, Baohua Yan, Miaomiao Pan, Yuanyuan Xu, Shilong Fan, Renhe Liu, Lan Xu, Lan Hua, Dirk Schnappinger , Shawn Chen
J Biol Chem DOI: https://doi.org/10.1016/j.jbc.2021.100257
2021/01/05
PNAS
Orthosteric–allosteric dual inhibitors of PfHT1 as selective antimalarial agents
Jian Huang, Yafei Yuan, Na Zhao… Tomoyo Sakata-Kato, Xin Jiang, Nobutaka Kato, Nieng Yan, and Hang Yin, el al.
PNAS DOI: https://doi.org/10.1073/pnas.2017749118
2020/12/16
Antimicrobial Agents and Chemotherapy
Development of a Simple In Vitro Assay To Identify and Evaluate Nucleotide Analogs against SARS-CoV-2 RNADependent RNA Polymerase
Gaofei Lu, Xi Zhang, Weinan Zheng, Jialei Sun, Lan Hua, Lan Xu, Xin-jie Chu, Sheng Ding, Wen Xiong
Antimicrobial Agents and Chemotherapy DOI: https://doi.org/10.1128/AAC.01508-20
2020/08/28
CELL
Structural Basis for Blocking Sugar Uptake into the Malaria Parasite Plasmodium falciparum
Xin Jiang, Yafei Yuan, Jian Huang… Nobutaka Kato, Hang Yin, Nieng Yan, el al.
CELL DOI: https://doi.org/10.1016/j.cell.2020.08.015
2019/05/08
Science Translational Medicine
Discovery of short-course antiwolbachial quinazolines for elimination of filarial worm infections
Malina A. Bakowski1, Roohollah Kazem Shiroodi, Renhe Liu, el al.
Science Translational Medicine DOI: https://doi.org/10.1126/scitranslmed.aav3523
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