About the Role

The successful candidate will primarily support the assay development and screening capabilities of the HTS Platform, using their scientific and technical skills to develop/optimize assays and carry out screening campaigns for internal projects, collaborations, and services to external customers. Additional support of other areas including cell culture and molecular biology is expected.

Key Responsibilities

• Design and develop fit for purpose assays in close collaboration with disease biology colleagues.

• Support all aspects of assay development and screening activities including assay optimization, validation, and execution on automation systems.

• Test and troubleshoot a variety of assay types, e.g. binding and competition assays, may use techniques such as reporter cell line, FP, AlphaLISA/AlphaScreen, FRET/HTRF based assays and ELISA.

• Use liquid handling automation to support high throughput screening.

• Contribute to laboratory process improvements.

• Support data management by analyzing data and recording within laboratory notebooks.

• Prepare reports and share with/present to project teams and collaborators.

• Assist related functions, e.g. cell culture, molecular biology, when required.

• Abide by Laboratory SOPs and work within EHS, Ethical and Quality standards.

Minimum Requirements

• MS in biological sciences (or equivalent) with 3 years of post-school laboratory working experience.

• Ability of follow instructions and create standard operating procedures.

• Good organizational and time management skills.

Preferred Qualifications

• MS with 5+ years or PhD with 2+ years of working experience in academic laboratories, CROs, or biotech/pharmaceutical industry.

• Track record of contributing to successful outcomes on projects.

• Experiences in developing assays and/or carrying out screening campaigns for drug discovery are highly desired.

• Comprehensive knowledge, understanding, and experience of modern liquid handling technologies is a big plus.

• Experience of carrying out data analysis such as multi-parameter curve fitting, EC50/IC50 determination, or using excel macro to handle large dataset is advantageous.

• Must possess and demonstrate strong written and verbal communication skills.

• Must be highly self-motivated and can work effectively in a collaborative team environment.

Location

Beijing, China

Key Responsibilities

• Determine the mode of action of antibacterial small molecules using systems biology techniques including metabolomics and genomics, etc.
• Design/synthesize or biosynthesize molecular probes to study the mechanisms of drug targets at both molecular and cellular levels.
• Develop novel biochemical assays for analysis of multi-component systems such as transcription, translation, respiration and cell membrane/wall biosynthesis.
• Broadly review anti-infective drug discovery literature, contribute to the initiation of new projects, organize and present project updates.

Minimum Requirements

• PhD degree in chemical biology, biochemistry, enzymology, microbial metabolism or the related microbiological sciences, preferably with at least 2-year postgraduate experience and project leading experience.
• Knowledge and experience in various bioanalytic techniques including LCMS, SPR, MST or large molecule NMR, etc is required or highly appreciated. Demonstrable skills in data analysis including programming and statistics would be a plus.
• Good team player, excellent collaboration and communication skills including fluent oral and written presentations in English.
• Scientific integrity is a must; the candidate should be professionally detail-oriented.

Location

Beijing, China

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